The Peptide Directory

Not an FDA-approved drugCoenzyme (dinucleotide)Longevity research

NAD+

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy metabolism, sold as supplements and compounded injections.

Last reviewed by The Peptide Directory Editorial Team

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy metabolism, sold as supplements and compounded injections. NAD+ is not an fda-approved drug; injectable products sold as "research use only" are not approved for human use.

NAD zwitterion is a NAD. It has a role as a geroprotector. It is functionally related to a deamido-NAD zwitterion. It is a conjugate base of a NAD(+).

Key takeaways

  1. NAD+ is not an fda-approved drug; injectable products sold as "research use only" are not approved for human use.
  2. PubMed indexes 17,148 papers on NAD+ (141 tagged as clinical trials) as of October 19, 2026.
  3. ClinicalTrials.gov lists 268 registered studies using NAD+.
  4. No vendor in our directory listed NAD+ when we checked.

Structure

2D chemical structure of NAD+ (C21H27N7O14P2), as depicted by PubChem
Structure: PubChem CID 5892 (C21H27N7O14P2, 663.4 g/mol). 2D depiction from NCBI PubChem, retrieved October 19, 2026.

Regulatory & access status

NAD+ is not an fda-approved drug; injectable products sold as "research use only" are not approved for human use.

Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.

How much research exists on NAD+?

PubMed indexes 17,148 papers mentioning NAD+ in the title or abstract, 4,931 of them from the last five years and 141 tagged as clinical trials (search run October 19, 2026; repeat the search).

Most relevant recent papers

Registered clinical studies

ClinicalTrials.gov lists 268 studies with NAD+ as an intervention (see all). Most recent:

What the evidence does not show

  • Paper counts measure research attention, not whether NAD+ works or is safe.
  • No FDA review of any "research use only" product's identity, purity, sterility or dose.

Research suppliers that list NAD+

None of the vendors in our directory listed NAD+ in their public catalog when we checked. The vendor directory records what each vendor publishes about testing.

NAD+ reconstitution math

Lab arithmetic only, not dosing guidance: vial-by-vial concentration tables are on NAD+ 500 mg vial math.

NAD+ FAQ

Is NAD+ FDA-approved?

NAD+ is not an fda-approved drug; injectable products sold as "research use only" are not approved for human use.

Is NAD+ safe?

Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.

How much research is there on NAD+?

PubMed indexes 17,148 papers on NAD+ (141 tagged as clinical trials) as of October 19, 2026.

Who sells NAD+?

None of the vendors in our directory listed it when we checked.

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