Not approved (research only)Mitochondrial-derived peptideLongevity research
Humanin
Humanin is a 24-amino-acid peptide encoded in mitochondrial DNA, studied in cell and animal models of cell survival and metabolism.
What is Humanin?
Humanin is a 24-amino-acid peptide encoded in mitochondrial DNA, studied in cell and animal models of cell survival and metabolism. Humanin is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Key takeaways
- Humanin is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
- PubMed indexes 549 papers on Humanin (8 tagged as clinical trials) as of October 19, 2026.
- ClinicalTrials.gov lists 3 registered studies using Humanin.
- 7 vendors in our directory listed Humanin in their public catalog on October 19, 2026.
Structure
Amino-acid sequence of Humanin, 24 residues: H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
Regulatory & access status
Humanin is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on Humanin?
PubMed indexes 549 papers mentioning Humanin in the title or abstract, 231 of them from the last five years and 8 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- Mitochondrial stress and mitokines in aging. — Aging Cell, 2023 · review
- Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease. — Alzheimers Res Ther, 2023 · clinical trial
- The role of humanin in the regulation of reproduction. — Biochim Biophys Acta Gen Subj, 2022 · review
- HUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation. — Cell Death Dis, 2025
- Humanin: Functional Interfaces with IGF-I. — Growth Horm IGF Res, 2016 · review
- Humanin and the receptors for humanin. — Mol Neurobiol, 2010 · review
Registered clinical studies
ClinicalTrials.gov lists 3 studies with Humanin as an intervention (see all). Most recent:
- Humanin Isoforms in Cardiac Muscle and Blood Plasma and Major Complications After Cardiac Operation — NCT03431844 · completed · started 2018-01-01
- Clinical Value of Plasma Humanin in Acute Kidney Injury — NCT06105229 · unknown · started 2022-08-01
- Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation — NCT07678073 · N/A · recruiting · started 2026-03-01
What the evidence does not show
- Paper counts measure research attention, not whether Humanin works or is safe.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list Humanin
7 vendors in our directory listed a product matching Humanin in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
- BioGenix Peptides
- Biotech Peptides
- Bulk Peptide Supply
- Core Peptides
- Peptide Partners
- Science.bio
- Xcel Peptides
Prices per mg, where we could verify them, are on our price comparison.
Humanin reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
Humanin FAQ
Is Humanin FDA-approved?
Humanin is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Is Humanin safe?
Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.
How much research is there on Humanin?
PubMed indexes 549 papers on Humanin (8 tagged as clinical trials) as of October 19, 2026.
Who sells Humanin?
BioGenix Peptides, Biotech Peptides, Bulk Peptide Supply, Core Peptides, Peptide Partners, Science.bio and 1 more listed it on their public catalogs when we checked; a listing is not an endorsement.
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