Semaglutide units converter (mg to U-100 units)

Last updated October 19, 2026. Reviewed by The Peptide Directory Editorial Team

At a concentration of 2.5 mg/mL, 0.25 mg of semaglutide is 0.1 mL, which is 10 units on a U-100 syringe.

Also called: semaglutide mg to units, semaglutide unit chart, compounded semaglutide units.

Result

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Reference chart

Units on a U-100 syringe = (mg ÷ mg/mL) × 100. Values above 100 units exceed a 1 mL syringe.
Mass (mg)	2 mg/mL	2.5 mg/mL	5 mg/mL	10 mg/mL
0.1	5 u	4 u	2 u	1 u
0.25	12.5 u	10 u	5 u	2.5 u
0.5	25 u	20 u	10 u	5 u
1	50 u	40 u	20 u	10 u
2	100 u	80 u	40 u	20 u
2.5	125 u	100 u	50 u	25 u

Semaglutide label steps expressed in syringe units

The FDA-approved product is a pen or single-dose device dosed in mg, so this conversion only applies when a vial is drawn with a U-100 syringe. Each mg step below is copied from the Semaglutide 2.4 mg schedule; the units are arithmetic at three example concentrations.

Semaglutide: label mg steps as U-100 units at 1, 2.5, 5 mg/mL
Step	mg	at 1 mg/mL	at 2.5 mg/mL	at 5 mg/mL
Weeks 1–4	0.25	25 u	10 u	5 u
Weeks 5–8	0.5	50 u	20 u	10 u
Weeks 9–12	1	100 u	40 u	20 u
Weeks 13–16	1.7	over 1 mL	68 u	34 u
Week 17 onward	2.4	over 1 mL	96 u	48 u
Wegovy HD (optional)	7.2	over 1 mL	over 1 mL	over 1 mL

U-100 syringe sizes

Every U-100 insulin syringe uses the same scale, 100 units per mL, so one unit is always 0.01 mL; only the barrel capacity differs. Choose a barrel that holds the full volume, because splitting a draw doubles the measuring error.

Capacity of common U-100 barrels and the largest mass each holds at 2.5 mg/mL
Barrel	Units	Max at 2.5 mg/mL
0.3 mL	30	0.75 mg
0.5 mL	50	1.25 mg
1 mL	100	2.5 mg

Micrograms: 1 mg = 1,000 mcg, so at 2.5 mg/mL each unit holds 25 mcg. Syringe units are not International Units (IU): IU measure biological activity and are defined per drug, as on hCG or somatropin labels.

Worked example

Example: 0.5 mg at 2.5 mg/mL → 0.5 ÷ 2.5 = 0.2 mL → 0.2 × 100 = 20 units.

How it works

1. Find the concentration
Read the concentration in mg/mL (from your own reconstitution arithmetic or the product documentation).
2. Convert mass to volume
Divide the mass in mg by the concentration in mg/mL to get milliliters.
3. Convert volume to units
Multiply milliliters by 100: a U-100 syringe has 100 units per mL.

Frequently asked questions

How many units is 1 mg?

It depends on concentration. Units = (mg ÷ concentration in mg/mL) × 100 on a U-100 syringe. At 5 mg/mL, 1 mg = 20 units; at 2 mg/mL, 1 mg = 50 units.

What is a U-100 syringe?

A syringe marked so that 100 units equal 1 mL; each unit is 0.01 mL.

Are units the same as IU?

No. Syringe "units" are volume markings (0.01 mL each on U-100). International Units (IU) measure biological activity and are drug-specific.

Does this calculator recommend a dose?

No. It converts numbers you enter. Dosing decisions belong to a licensed clinician.

Is Semaglutide measured in units?

FDA-approved Semaglutide pens are dosed in mg. Syringe units only apply when a vial (compounded or research product) is drawn with a U-100 syringe, and depend on its concentration.

Sources

Reconstitution, units and concentration arithmetic: see our lab-handling guide, The Peptide Directory

Label and trial dose references

See the Semaglutide profile and Semaglutide prices per mg. For doses as printed in FDA labels or used in trials, see the peptide dose reference and the protocol pages.

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