TB-500

Structure

What makes TB-500 different?

The parent protein thymosin beta-4 has been tested in formal clinical development (for example in eye-surface disease), but TB-500 itself — the product sold online — has not.

How does TB-500 work?

Thymosin beta-4 sequesters G-actin, which influences cell movement, new blood-vessel formation and inflammation in experimental models.

What the clinical evidence actually shows

• Reviews describe the biology of beta-thymosins and the bench-to-bedside path of thymosin beta-4 in eye disease.
• No adequately powered human trials of the product sold as TB-500 for musculoskeletal recovery were identified.

How much research exists on TB-500 (thymosin beta-4 fragment)?

PubMed indexes 602 papers mentioning TB-500 (thymosin beta-4 fragment) in the title or abstract, 92 of them from the last five years and 3 tagged as clinical trials (search run October 19, 2026; repeat the search).

Most relevant recent papers

• Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids. — Stem Cell Reports, 2025
• Recombinant human thymosin beta 4 improves ischemic cardiac dysfunction in mice and patients with acute ST-segment elevation myocardial infarction after reperfusion. — Cardiovasc Res, 2025
• Thymosin β(4) and β(10) Expression in Human Organs during Development: A Review. — Cells, 2024 · review
• The beta-thymosin enigma. — Ann N Y Acad Sci, 2007 · review
• Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies. — Int Immunopharmacol, 2023 · review
• Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. — Sports Med, 2026 · review

Registered clinical studies

ClinicalTrials.gov lists 18 studies with TB-500 (thymosin beta-4 fragment) as an intervention (see all). Most recent:

• A Phase 1 Safety Study of the Intravenous Administration of Thymosin Beta in Healthy Volunteers — NCT00743769 · Phase 1 · withdrawn · started 2008-04
• Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2 — NCT02974907 · Phase 3 · completed · started 2016-11
• A Phase 2 Study of the Safety and Efficacy of Thymosin Beta 4 for Treating Corneal Wounds — NCT00598871 · Phase 2 · terminated · started 2007-12
• Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2 — NCT05555589 · Phase 3 · recruiting · started 2023-04-11
• Efficacy and Safety Study of Thymosin Beta 4 in Patients With Acute Myocardial Infarction — NCT05984134 · Phase 2 · completed · started 2022-07-15

Side effects

Human safety data for TB-500 products are lacking. Risks include unknown long-term effects and impurity or mislabeling in unregulated supply.

Regulatory & access status

• Not FDA-approved.
• July 23, 2026: included in the 8–6 advisory vote recommending the 503A bulks list; not yet adopted by FDA.

Sourcing & safety

Sold online as a research chemical, not for human use. Verify any vendor COA for identity (mass spectrometry), not just HPLC purity.

Doses in labels and trials

Reference only — copied from published research. Not a recommendation.

What the evidence does not show

• Effectiveness of TB-500 products for injury recovery in humans.
• Equivalence between "TB-500" products and thymosin beta-4.
• Long-term safety.

TB-500 FAQ

Related peptides & comparisons

BPC-157GHK-Cu BPC-157 vs TB-500 Injury & Recovery

References

1. beta-Thymosins, Ann N Y Acad Sci (2007), PMID 17468232
2. Thymosin beta 4 and the eye: the journey from bench to bedside, Expert Opin Biol Ther (2018), PMID 30063853
3. July 23–24, 2026: Meeting of the Pharmacy Compounding Advisory Committee, FDA (2026)
4. FDA Panel Backs 6 Peptides for Compounding, AJMC (2026)
5. Thymosin beta-4 — PubChem compound summary (CID 45382195), PubChem

TB-500 calculators

Lab arithmetic only: convert a mass to a volume or syringe units at a known concentration with the units converter, or work out a concentration with the reconstitution calculator.

Where to get TB-500 legally

There is no FDA-approved TB-500 product. Compounded versions depend on FDA's compounding rules, and "research use only" products are not for human use.

Get TB-500 via telehealth

None of the telehealth providers we have verified lists TB-500.

Research suppliers that list TB-500

43 vendors in our directory listed a product matching TB-500 in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.

• Amino AmigosCatalog item: “TB 500 5mg”
• Ascension PeptidesCatalog item: “TB-500 (5MG)”
• Atomik LabzCatalog item: “BULK PACK TB-500 (Thymosin Beta-4) (43 AA) – 10mg (10 VIALS)”
• Backroad AminosCatalog item: “TB-500 10mg”
• BioGenix PeptidesCatalog item: “TB-500 10mg”
• BioLongevity LabsCatalog item: “TB-500 (10mg)”
• Biotech PeptidesCatalog item: “TB-500 (Thymosin Beta-4) (5mg)”
• Bulk Peptide SupplyCatalog item: “TB-500 10 mg”
• CostidesCatalog item: “TB-500”
• Dynamic PeptideCatalog item: “TB-500 Peptide 10mg”
• Eros PeptidesCatalog item: “TB-500 20MG”
• Evolve BioPepCatalog item: “TB-500 10mg”
• Extreme PeptidesCatalog item: “Thymosin Beta-4 — Full-Length (43 aa; TB-500) 5mg”
• JetPepsCatalog item: “TB-500 10mg”
• Liberty PeptidesCatalog item: “TB-500 (Thymosin Beta-4)”
• Licensed PeptidesCatalog item: “TB-500 (Thymosin Beta-4) 10mg (10 vials)”
• LotusPeptideCatalog item: “TB-500 5mg”
• Modern AminosCatalog item: “TB-500 (Thymosin Beta-4)”
• NuScience PeptidesCatalog item: “TB500 Peptide – Research-Grade Thymosin Beta-4 – 5mg | 10mg”
• OmegAminoCatalog item: “OmA – TB-500”
• Paramount PeptidesCatalog item: “Thymosin Beta 4 (TB500) (10mg)”
• Peptide CraftersCatalog item: “TB-500 – Thymosin Beta-4 (10mg)”
• Peptide PartnersCatalog item: “TB-500 (TB4, 10mg vials)”
• Peptide WorldwideCatalog item: “TB500 5MG (Thyomosin Beta 4) – 5MG per vial”
• Peptide.ExpressCatalog item: “TB-500 5mg”
• Pharma Grade PeptidesCatalog item: “TB-500 (Thymosin Beta-4) 10MG”
• Pinnacle Peptide LabsCatalog item: “TB-500 [5mg]”
• Polaris PeptidesCatalog item: “TB-500 10mg”
• Prime Lab PeptidesCatalog item: “TB-500 – 10mg”
• Prime PeptidesCatalog item: “TB-500 (TB4)”
• ProtideHealthCatalog item: “TB-500 (Thymosin Beta-4) 10mg”
• Pure Lab PeptidesCatalog item: “TB-500 10mg”
• Ramp PeptidesCatalog item: “TB-500”
• Royal PeptidesCatalog item: “TB-500 10mgx10vials”
• San Diego PeptidesCatalog item: “TB-500 (Thymosin β4)”
• Southern AminosCatalog item: “TB-500 10mg”
• Sports Technology LabsCatalog item: “TB-500 5 mg”
• Sunrise BioResearchCatalog item: “TB-500 10mg x 10vials, 100mg”
• Swiss ChemsCatalog item: “TB-500 (Thymosin Beta-4)”
• Trusted PeptideCatalog item: “TB-500 5mg”
• Verified PeptidesCatalog item: “TB-500 Peptide (TB4) 10MG”
• Voltera SciencesCatalog item: “TB-500 10MG”
• Xcel PeptidesCatalog item: “TB-500”

Prices per mg, where we could verify them, are on our price comparison.

TB-500 dosing protocol

There is no FDA-label or published-trial dosing schedule we can reproduce for TB-500, so we don't publish one.

Find clinics offering TB-500

• Saguaro Medical Weight Control, semaglutide, phentermineAvondale, AZ — named on the clinic's own website
• Saguaro Medical Weight Control, Semaglutide, PhentermineMesa, AZ — named on the clinic's own website
• Saguaro Medical Weight Control, Semaglutide, PhenterminePhoenix, AZ — named on the clinic's own website
• Joint Restore ClinicSanta Ana, CA — named on the clinic's own website
• DNA Wellness and Longevity InstituteBonita Springs, FL — named on the clinic's own website
• Florida Bariatric And Plastic Surgery MDFort Lauderdale, FL — named on the clinic's own website
• Pure HydrationJacksonville, FL — named on the clinic's own website
• Aspire Rejuvenation Clinic - OrlandoOrlando, FL — named on the clinic's own website
• Choiceone Medspa OrlandoOrlando, FL — named on the clinic's own website
• Rejuvenate Wellness CenterOrlando, FL — named on the clinic's own website
• Infinite Health Integrative Medicine Center New OrleansMetairie, LA — named on the clinic's own website
• Body by BarkerTowson, MD — named on the clinic's own website

22 verified clinics name TB-500; browse them by state.

Browse all clinics