Not approved (research only)MIF-1 analogSkin research
Melanostatin DM
Melanostatin DM is a cosmetic analog of MIF-1 (melanocyte-inhibiting factor) used in skin-brightening products.
What is Melanostatin DM?
Melanostatin DM is a cosmetic analog of MIF-1 (melanocyte-inhibiting factor) used in skin-brightening products. Melanostatin DM is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Key takeaways
- Melanostatin DM is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
- PubMed indexes 60 papers on Melanostatin DM (0 tagged as clinical trials) as of October 19, 2026.
- No vendor in our directory listed Melanostatin DM when we checked.
Structure
Amino-acid sequence of Melanostatin DM, 3 residues: H-Pro-Leu-Gly-NH2
Regulatory & access status
Melanostatin DM is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on Melanostatin DM?
PubMed indexes 60 papers mentioning Melanostatin DM in the title or abstract, 8 of them from the last five years and 0 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents. — J Physiol, 1994
- [Modification of melanostatin]. — Bioorg Khim, 1992 · review
- Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D(2) Receptors. — ACS Med Chem Lett, 2023
- Nuclear-magnetic-resonance study of aggregations and conformations of melanostatin and related peptides. — Eur J Biochem, 1978
- Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D(2) Receptors. — ACS Med Chem Lett, 2025
- Neurodegeneration in familial amyloidotic polyneuropathy. — Clin Exp Pharmacol Physiol, 2012 · review
What the evidence does not show
- Paper counts measure research attention, not whether Melanostatin DM works or is safe.
- No clinical trial in humans is tagged in PubMed under this name.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list Melanostatin DM
None of the vendors in our directory listed Melanostatin DM in their public catalog when we checked. The vendor directory records what each vendor publishes about testing.
Melanostatin DM reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
Melanostatin DM FAQ
Is Melanostatin DM FDA-approved?
Melanostatin DM is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Is Melanostatin DM safe?
There are no published human safety trials of Melanostatin DM that we could find. Products sold as "research use only" have no FDA review of purity, sterility or dose, and are not for human use.
How much research is there on Melanostatin DM?
PubMed indexes 60 papers on Melanostatin DM (0 tagged as clinical trials) as of October 19, 2026.
Who sells Melanostatin DM?
None of the vendors in our directory listed it when we checked.
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