Not approved (research only)Cosmetic lipopeptideSkin research
Matrixyl (palmitoyl pentapeptide-4)
Matrixyl (palmitoyl pentapeptide-4) is a cosmetic lipopeptide used in topical skin-care products.
What is Matrixyl?
Matrixyl (palmitoyl pentapeptide-4) is a cosmetic lipopeptide used in topical skin-care products. Matrixyl (palmitoyl pentapeptide-4) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Key takeaways
- Matrixyl (palmitoyl pentapeptide-4) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
- PubMed indexes 5 papers on Matrixyl (0 tagged as clinical trials) as of October 19, 2026.
- 5 vendors in our directory listed Matrixyl in their public catalog on October 19, 2026.
Structure
Regulatory & access status
Matrixyl (palmitoyl pentapeptide-4) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on Matrixyl (palmitoyl pentapeptide-4)?
PubMed indexes 5 papers mentioning Matrixyl (palmitoyl pentapeptide-4) in the title or abstract, 5 of them from the last five years and 0 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides. — Adv Sci (Weinh), 2025
- Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet. — J Clin Aesthet Dermatol, 2023
- Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study. — Molecules, 2025
- Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin. — Acta Biomater, 2025
- A framework for the safety evaluation of peptides in cosmetics. — Curr Res Toxicol, 2026
What the evidence does not show
- Paper counts measure research attention, not whether Matrixyl works or is safe.
- No clinical trial in humans is tagged in PubMed under this name.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list Matrixyl
5 vendors in our directory listed a product matching Matrixyl in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
Prices per mg, where we could verify them, are on our price comparison.
Matrixyl reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
Matrixyl FAQ
Is Matrixyl FDA-approved?
Matrixyl (palmitoyl pentapeptide-4) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Is Matrixyl safe?
There are no published human safety trials of Matrixyl that we could find. Products sold as "research use only" have no FDA review of purity, sterility or dose, and are not for human use.
How much research is there on Matrixyl?
PubMed indexes 5 papers on Matrixyl (0 tagged as clinical trials) as of October 19, 2026.
Who sells Matrixyl?
Atomik Labz, Biotech Peptides, Core Peptides, Ion Peptide, Verified Peptides listed it on their public catalogs when we checked; a listing is not an endorsement.
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