Not approved (research only)Cosmetic peptideSkin research
Argireline (acetyl hexapeptide-3)
Argireline (acetyl hexapeptide-3/-8) is a cosmetic peptide used in topical products marketed against expression lines.
What is Argireline?
Argireline (acetyl hexapeptide-3/-8) is a cosmetic peptide used in topical products marketed against expression lines. Argireline (acetyl hexapeptide-3) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Key takeaways
- Argireline (acetyl hexapeptide-3) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
- PubMed indexes 8 papers on Argireline (1 tagged as clinical trials) as of October 19, 2026.
- ClinicalTrials.gov lists 7 registered studies using Argireline.
- 4 vendors in our directory listed Argireline in their public catalog on October 19, 2026.
Structure
Regulatory & access status
Argireline (acetyl hexapeptide-3) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on Argireline (acetyl hexapeptide-3)?
PubMed indexes 8 papers mentioning Argireline (acetyl hexapeptide-3) in the title or abstract, 3 of them from the last five years and 1 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study. — J Cosmet Dermatol, 2017 · clinical trial
- Facial rejuvenation: combining cosmeceuticals with cosmetic procedures. — Cutis, 2014 · review
- Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts. — Skin Pharmacol Physiol, 2021
- Development of a Sensory Neuron-Integrated Skin Spheroid Model for the Evaluation of Neuropeptide-Based Topical Delivery Systems. — ACS Biomater Sci Eng, 2025
- Geometrical optimisation of a personalised microneedle eye patch for transdermal delivery of anti-wrinkle small peptide. — Biofabrication, 2020
- High resolution photopolymer for 3D printing of personalised microneedle for transdermal delivery of anti-wrinkle small peptide. — J Control Release, 2021
Registered clinical studies
ClinicalTrials.gov lists 7 studies with Argireline (acetyl hexapeptide-3) as an intervention (see all). Most recent:
- Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily Skin — NCT02597777 · N/A · completed · started 2016-01
- Acetyl Hexapeptide-8 for Blepharospasm — NCT01750346 · Phase 2 · terminated · started 2012-11
- A Clinical Trial to Evaluate the Effects of an Eye Serum on Improving the Appearance of the Periorbital Area — NCT06143033 · N/A · completed · started 2023-08-21
- AI-Personalized Skincare Regimen for Facial Photoaging in Women — NCT07879833 · N/A · completed · started 2025-09-30
- Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream — NCT03878381 · Early phase 1 · completed · started 2019-04-01
What the evidence does not show
- Paper counts measure research attention, not whether Argireline works or is safe.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list Argireline
4 vendors in our directory listed a product matching Argireline in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
Prices per mg, where we could verify them, are on our price comparison.
Argireline reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
Argireline FAQ
Is Argireline FDA-approved?
Argireline (acetyl hexapeptide-3) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Is Argireline safe?
Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.
How much research is there on Argireline?
PubMed indexes 8 papers on Argireline (1 tagged as clinical trials) as of October 19, 2026.
Who sells Argireline?
Atomik Labz, Biotech Peptides, Core Peptides, Verified Peptides listed it on their public catalogs when we checked; a listing is not an endorsement.
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