Not approved (research only)Oral ghrelin-receptor agonist (non-peptide)Growth hormone research
MK-677 (ibutamoren)
MK-677 (ibutamoren) is an orally active, non-peptide ghrelin-receptor agonist that raises growth hormone and IGF-1; it is not FDA-approved.
What is MK-677?
MK-677 (ibutamoren) is an orally active, non-peptide ghrelin-receptor agonist that raises growth hormone and IGF-1; it is not FDA-approved. MK-677 (ibutamoren) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Key takeaways
- MK-677 (ibutamoren) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
- PubMed indexes 30 papers on MK-677 (3 tagged as clinical trials) as of October 19, 2026.
- ClinicalTrials.gov lists 8 registered studies using MK-677.
- 5 vendors in our directory listed MK-677 in their public catalog on October 19, 2026.
Structure
Regulatory & access status
MK-677 (ibutamoren) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on MK-677 (ibutamoren)?
PubMed indexes 30 papers mentioning MK-677 (ibutamoren) in the title or abstract, 19 of them from the last five years and 3 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- Peptide Supplements and Their Therapeutic Applications in Sports Medicine. — Am J Sports Med, 2026
- Characterization of growth hormone secretagogue small molecule ibutamoren (MK-0677) and its possible metabolites in thoroughbred horses for doping control. — Rapid Commun Mass Spectrom, 2022
- Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren. — Nat Commun, 2021
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. — Transl Androl Urol, 2020 · review
- Characterization of equine liver microsome-generated metabolites of growth hormone secretagogue small molecule ibutamoren. — Rapid Commun Mass Spectrom, 2021
- Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children. — Clin Pharmacol Ther, 2001 · clinical trial
Registered clinical studies
ClinicalTrials.gov lists 8 studies with MK-677 (ibutamoren) as an intervention (see all). Most recent:
- Treatment of Sarcopenia in Post-Hip Fracture Patients (0677-032) — NCT00128115 · Phase 2 · terminated · started 2005-09
- Efficacy and Safety of an Oral Growth Hormone Drug in the Treatment of Fibromyalgia — NCT00116129 · Phase 2 · completed · started 2005-07
- Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency — NCT06948214 · Phase 3 · recruiting · started 2026-05-20
- Study of MK0677 for the Treatment of Alzheimer's Disease (0677-030)(COMPLETED) — NCT00074529 · Phase 2 · completed · started 2003-10
- Effects of an Oral GH Secretagogue (MK-677) on Body Composition and Functional Ability of Older Adults — NCT00474279 · Phase 1/Phase 2 · completed · started 1998-07
What the evidence does not show
- Paper counts measure research attention, not whether MK-677 works or is safe.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list MK-677
5 vendors in our directory listed a product matching MK-677 in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
Prices per mg, where we could verify them, are on our price comparison.
MK-677 reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
MK-677 FAQ
Is MK-677 FDA-approved?
MK-677 (ibutamoren) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Is MK-677 safe?
Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.
How much research is there on MK-677?
PubMed indexes 30 papers on MK-677 (3 tagged as clinical trials) as of October 19, 2026.
Who sells MK-677?
Extreme Peptides, Liberty Peptides, Modern Aminos, Science.bio, Sports Technology Labs listed it on their public catalogs when we checked; a listing is not an endorsement.
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