Not approved (research only)IGF-1 splice variantMuscle research
MGF (mechano growth factor)
Mechano growth factor (MGF) is a splice variant of IGF-1 expressed in muscle after mechanical load; research is preclinical.
What is MGF?
Mechano growth factor (MGF) is a splice variant of IGF-1 expressed in muscle after mechanical load; research is preclinical. MGF (mechano growth factor) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Key takeaways
- MGF (mechano growth factor) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
- PubMed indexes 194 papers on MGF (6 tagged as clinical trials) as of October 19, 2026.
- ClinicalTrials.gov lists 105 registered studies using MGF.
- 8 vendors in our directory listed MGF in their public catalog on October 19, 2026.
Regulatory & access status
MGF (mechano growth factor) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on MGF (mechano growth factor)?
PubMed indexes 194 papers mentioning MGF (mechano growth factor) in the title or abstract, 19 of them from the last five years and 6 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- Mechano-growth factor regulates periodontal ligament stem cell proliferation and differentiation through Fyn-RhoA-YAP signaling. — Biochem Biophys Res Commun, 2024
- The role of mechano growth factor in chondrocytes and cartilage defects: a concise review. — Acta Biochim Biophys Sin (Shanghai), 2023 · review
- Mechano-growth factor E-domain modulates cardiac contractile function through 14-3-3 protein interactomes. — Front Physiol, 2022
- Mechano growth factor interacts with nucleolin to protect against cisplatin-induced neurotoxicity. — Exp Neurol, 2020
- Mechano Growth Factor Accelerates ACL Repair and Improves Cell Mobility of Mechanically Injured Human ACL Fibroblasts by Targeting Rac1-PAK1/2 and RhoA-ROCK1 Pathways. — Int J Mol Sci, 2022
- Mechano-growth factor E peptide promotes healing of rat injured tendon. — Biotechnol Lett, 2016
Registered clinical studies
ClinicalTrials.gov lists 105 studies with MGF (mechano growth factor) as an intervention (see all). Most recent:
- Study of VF001-DP in Patients With Chronic Venous Leg Ulcers — NCT02973893 · Phase 2 · unknown · started 2016-11
- Patellar Tendinopathy - Effect of Training and Enhancement of the Collagen Synthesis by Insulin-like Growth Factor-I — NCT01834989 · Early phase 1 · unknown · started 2013-04
- Low Dose Growth Hormone (GH) on Insulin Sensitivity and Cortisol Production Rates — NCT00517062 · Early phase 1 · completed · started 2006-01
- Establishment of Reference Values for Insulin-like Growth Factor 1 (IGF1) in the General Population — NCT01831648 · N/A · completed · started 2010-05
- Effect of Pegvisomant on GH/IGF-I Relationship in GHD — NCT00468624 · N/A · terminated · started 2004-12
What the evidence does not show
- Paper counts measure research attention, not whether MGF works or is safe.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list MGF
8 vendors in our directory listed a product matching MGF in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
- Biotech Peptides
- Core Peptides
- Extreme Peptides
- Paramount Peptides
- Peptide Worldwide
- Pharma Grade Peptides
- Pure Lab Peptides
- Swiss Chems
Prices per mg, where we could verify them, are on our price comparison.
MGF reconstitution math
Lab arithmetic only, not dosing guidance: vial-by-vial concentration tables are on MGF 5 mg vial math.
MGF FAQ
Is MGF FDA-approved?
MGF (mechano growth factor) is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Is MGF safe?
Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.
How much research is there on MGF?
PubMed indexes 194 papers on MGF (6 tagged as clinical trials) as of October 19, 2026.
Who sells MGF?
Biotech Peptides, Core Peptides, Extreme Peptides, Paramount Peptides, Peptide Worldwide, Pharma Grade Peptides and 2 more listed it on their public catalogs when we checked; a listing is not an endorsement.
Related compounds
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