Not FDA-approved (approved in Russia)ACTH(4-10) analogCognitive research
Semax
Semax is a synthetic analog of ACTH(4-10) used in Russia as a nasal drug; it is not approved in the US.
What is Semax?
Semax is a synthetic analog of ACTH(4-10) used in Russia as a nasal drug; it is not approved in the US. Semax is not approved by the FDA (approved in Russia); products sold online in the US are labeled for research use only.
Key takeaways
- Semax is not approved by the FDA (approved in Russia); products sold online in the US are labeled for research use only.
- PubMed indexes 209 papers on Semax (4 tagged as clinical trials) as of October 19, 2026.
- 43 vendors in our directory listed Semax in their public catalog on October 19, 2026.
Structure
Amino-acid sequence of Semax, 7 residues: H-Met-Glu-His-Phe-Pro-Gly-Pro-OH
Regulatory & access status
Semax is not approved by the FDA (approved in Russia); products sold online in the US are labeled for research use only.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on Semax?
PubMed indexes 209 papers mentioning Semax in the title or abstract, 34 of them from the last five years and 4 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. — J Am Acad Orthop Surg Glob Res Rev, 2026 · review
- Functional Connectomic Approach to Studying Selank and Semax Effects. — Dokl Biol Sci, 2020
- Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. — Br J Pharmacol, 2025
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging. — Front Aging, 2026 · review
- The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. — Bull Exp Biol Med, 2025
- Brain Protein Expression Profile Confirms the Protective Effect of the ACTH((4-7))PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion. — Int J Mol Sci, 2021
What the evidence does not show
- Paper counts measure research attention, not whether Semax works or is safe.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list Semax
43 vendors in our directory listed a product matching Semax in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
- Ascension Peptides
- Atomik Labz
- Backroad Aminos
- Biocollex Research
- BioGenix Peptides
- BioLongevity Labs
- Biotech Peptides
- Bulk Peptide Supply
- Core Peptides
- Costides
- Dynamic Peptide
- Eros Peptides
- Evolve BioPep
- Extreme Peptides
- JetPeps
- Liberty Peptides
- Licensed Peptides
- LotusPeptide
- Modern Aminos
- NuScience Peptides
- OmegAmino
- Paramount Peptides
- Peptide Crafters
- Peptide Partners
- Peptide.Express
- Pharma Grade Peptides
- Pinnacle Peptide Labs
- Plum Labs Research
- Polaris Peptides
- Prime Lab Peptides
- Prime Peptides
- ProtideHealth
- Pure Lab Peptides
- Ramp Peptides
- Royal Peptides
- San Diego Peptides
- Science.bio
- Southern Aminos
- Sports Technology Labs
- Sunrise BioResearch
- Swiss Chems
- Voltera Sciences
- Xcel Peptides
Prices per mg, where we could verify them, are on our price comparison.
Semax reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
Semax FAQ
Is Semax FDA-approved?
Semax is not approved by the FDA (approved in Russia); products sold online in the US are labeled for research use only.
Is Semax safe?
Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.
How much research is there on Semax?
PubMed indexes 209 papers on Semax (4 tagged as clinical trials) as of October 19, 2026.
Who sells Semax?
Ascension Peptides, Atomik Labz, Backroad Aminos, Biocollex Research, BioGenix Peptides, BioLongevity Labs and 37 more listed it on their public catalogs when we checked; a listing is not an endorsement.
Head-to-head comparisons
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