Not approved (research only)Spadin analogMood research
PE-22-28
PE-22-28 is a shortened analog of spadin, a peptide that blocks the TREK-1 channel, studied in mouse depression models.
What is PE-22-28?
PE-22-28 is a shortened analog of spadin, a peptide that blocks the TREK-1 channel, studied in mouse depression models. PE-22-28 is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Key takeaways
- PE-22-28 is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
- PE-22-28 has little indexed research under its own name; we list only papers whose titles name it.
- 13 vendors in our directory listed PE-22-28 in their public catalog on October 19, 2026.
Regulatory & access status
PE-22-28 is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on PE-22-28?
PE-22-28 has no reliable PubMed search term of its own (the name is shared with unrelated terms), so we list only papers whose titles name it. Search PubMed.
Most relevant recent papers
- Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin. — Pharmacol Ther, 2019 · review
What the evidence does not show
- Paper counts measure research attention, not whether PE-22-28 works or is safe.
- No clinical trial in humans is tagged in PubMed under this name.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list PE-22-28
13 vendors in our directory listed a product matching PE-22-28 in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
- Atomik Labz
- Backroad Aminos
- Biotech Peptides
- Bulk Peptide Supply
- Core Peptides
- Eros Peptides
- Ion Peptide
- Modern Aminos
- Paramount Peptides
- Polaris Peptides
- Pure Lab Peptides
- Southern Aminos
- Xcel Peptides
Prices per mg, where we could verify them, are on our price comparison.
PE-22-28 reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
PE-22-28 FAQ
Is PE-22-28 FDA-approved?
PE-22-28 is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
Is PE-22-28 safe?
There are no published human safety trials of PE-22-28 that we could find. Products sold as "research use only" have no FDA review of purity, sterility or dose, and are not for human use.
How much research is there on PE-22-28?
PE-22-28 has little indexed research under its own name; we list only papers whose titles name it.
Who sells PE-22-28?
Atomik Labz, Backroad Aminos, Biotech Peptides, Bulk Peptide Supply, Core Peptides, Eros Peptides and 7 more listed it on their public catalogs when we checked; a listing is not an endorsement.
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