PNC-27

Regulatory & access status

PNC-27 is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.

Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.

How much research exists on PNC-27?

PubMed indexes 23 papers mentioning PNC-27 in the title or abstract, 8 of them from the last five years and 0 tagged as clinical trials (search run October 19, 2026; repeat the search).

Most relevant recent papers

• PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis. — Biomedicines, 2022
• Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing Mitochondrial Disruption. — Ann Clin Lab Sci, 2024
• Conjugated PNC-27 peptide/PEI-superparamagnetic iron oxide nanoparticles (SPIONs) as a double targeting agent for early cancer diagnosis: In vitro study. — Iran J Basic Med Sci, 2022
• HDM-2-Targeting Peptide PNC-27 Kills Cervical Cancer Cells but not Normal Cervical Cells. — Ann Clin Lab Sci, 2025
• The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells. — Ann Clin Lab Sci, 2014
• Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. — Anticancer Res, 2020

What the evidence does not show

• Paper counts measure research attention, not whether PNC-27 works or is safe.
• No clinical trial in humans is tagged in PubMed under this name.
• No FDA review of any "research use only" product's identity, purity, sterility or dose.

Research suppliers that list PNC-27

14 vendors in our directory listed a product matching PNC-27 in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.

• Atomik LabzCatalog item: “BULK PACK PNC-27 – 10mg (10 VIALS)”
• BioLongevity LabsCatalog item: “PNC-27 (10mg)”
• Biotech PeptidesCatalog item: “PNC-27 (5mg)”
• Bulk Peptide SupplyCatalog item: “PNC-27 5 mg”
• Core PeptidesCatalog item: “PNC-27 – 5MG”
• Eros PeptidesCatalog item: “PNC-27 5MG”
• Evolve BioPepCatalog item: “PNC-27 5mg”
• Liberty PeptidesCatalog item: “PNC-27 (10mg)”
• NuScience PeptidesCatalog item: “PNC-27 – 30mg”
• Pharma Grade PeptidesCatalog item: “PNC-27 5MG”
• Polaris PeptidesCatalog item: “PNC-27 10mg”
• Pure Lab PeptidesCatalog item: “PNC-27 30mg”
• Science.bioCatalog item: “PNC-27 – Aliquot, 5mg”
• Xcel PeptidesCatalog item: “PNC-27 10mg”

Prices per mg, where we could verify them, are on our price comparison.

PNC-27 reconstitution math

Lab arithmetic only, not dosing guidance: vial-by-vial concentration tables are on PNC-27 10 mg vial math.

PNC-27 FAQ

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