Lab arithmeticPNC-27Not approved (research only)
PNC-27 10 mg: dosing evidence and reconstitution math
A 10 mg vial of PNC-27 mixed with 2 mL of diluent is 5 mg/mL, so 10 units on a U-100 syringe (0.1 mL) contain 500 mcg.
Is there an established dose?
No FDA label or published human trial defines a dose of PNC-27, so we do not publish one. Online "protocols" for it are not evidence.
- PNC-27 profile: FDA status, research volume and registered trials.
10 mg vial concentration table
Concentration = vial content ÷ diluent volume. A U-100 insulin syringe holds 1 mL in 100 units, so 1 unit = 0.01 mL.
| Diluent | Concentration | Per 10 units (0.1 mL) | Per 1 unit |
|---|---|---|---|
| 1 mL | 10 mg/mL | 1 mg | 100 mcg |
| 2 mL | 5 mg/mL | 500 mcg | 50 mcg |
| 3 mL | 3.333 mg/mL | 333 mcg | 33.3 mcg |
| 5 mL | 2 mg/mL | 200 mcg | 20 mcg |
Arithmetic only; it assumes the vial contains exactly what the label states. Independent tests often find vials under- or over-filled, which is why a lot's certificate of analysis matters.
Syringe units for a given amount
Units on a U-100 syringe needed to draw each amount from this 10 mg vial, by diluent volume. The amounts are fractions of the vial (1/50, 1/20, 1/10, 1/5), not dose suggestions.
| Amount | 1 mL diluent | 2 mL diluent | 3 mL diluent |
|---|---|---|---|
| 200 mcg | 2 units | 4 units | 6 units |
| 500 mcg | 5 units | 10 units | 15 units |
| 1 mg | 10 units | 20 units | 30 units |
| 2 mg | 20 units | 40 units | 60 units |
Units = amount ÷ concentration × 100. Draws above 100 units exceed a 1 mL syringe.
What the research covers
A PubMed search for "PNC-27"[tiab] returned 23 records (8 from the last five years), none indexed as clinical trials when checked on October 2026. That is a very small literature; most of it is cell or animal work.
- PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis.
- Anti-Cancer Peptide PNC-27 Kills Cancer Cells by Unique Interactions with Plasma Membrane-Bound hdm-2 and with Mitochondrial Membranes Causing Mitochondrial Disruption.
- Conjugated PNC-27 peptide/PEI-superparamagnetic iron oxide nanoparticles (SPIONs) as a double targeting agent for early cancer diagnosis: In vitro study.
- HDM-2-Targeting Peptide PNC-27 Kills Cervical Cancer Cells but not Normal Cervical Cells.
- The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.
Where research vials are listed
14 suppliers in our directory list PNC-27 (A–Z): Atomik Labz, BioLongevity Labs, Biotech Peptides, Bulk Peptide Supply, Core Peptides, Eros Peptides, Evolve BioPep, Liberty Peptides, and 6 more. A listing is not a quality endorsement; ask for a lot-specific certificate of analysis.
Storage & handling
Follow the storage statement on the product sheet or certificate of analysis. Lyophilized (freeze-dried) peptides are generally kept cold, dry and away from light; once reconstituted, stability is shorter and depends on the compound and diluent. Bacteriostatic water contains 0.9% benzyl alcohol as a preservative; sterile water does not.
Frequently asked questions
How much bacteriostatic water for a 10 mg PNC-27 vial?
The diluent volume only sets the concentration: 1 mL gives 10 mg/mL, 2 mL gives 5 mg/mL and 3 mL gives 3.333 mg/mL. Smaller volumes are more concentrated, so each syringe unit holds more.
How much PNC-27 is in 10 units?
At 2 mL of diluent, 10 units (0.1 mL) of a 10 mg vial contain 500 mcg; at 1 mL they contain 1 mg.
What is the dose of PNC-27?
No FDA label or published human trial defines a dose of PNC-27, so we do not publish one. Online "protocols" for it are not evidence.