The Peptide Directory

Not approved (research only)Melanocortin agonist peptideTanning research

Melanotan II

Melanotan II is a synthetic melanocortin-receptor agonist that darkens skin; it is unapproved and regulators have warned against its use.

Last reviewed by The Peptide Directory Editorial Team

What is Melanotan II?

Melanotan II is a synthetic melanocortin-receptor agonist that darkens skin; it is unapproved and regulators have warned against its use. Melanotan II is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.

Key takeaways

  1. Melanotan II is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.
  2. PubMed indexes 196 papers on Melanotan II (4 tagged as clinical trials) as of October 19, 2026.
  3. 36 vendors in our directory listed Melanotan II in their public catalog on October 19, 2026.

Structure

2D chemical structure of Melanotan II (C50H69N15O9), as depicted by PubChem
Structure: PubChem CID 92432 (C50H69N15O9, 1,024.2 g/mol). 2D depiction from NCBI PubChem, retrieved October 19, 2026.

Regulatory & access status

Melanotan II is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.

Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.

How much research exists on Melanotan II?

PubMed indexes 196 papers mentioning Melanotan II in the title or abstract, 29 of them from the last five years and 4 tagged as clinical trials (search run October 19, 2026; repeat the search).

Most relevant recent papers

What the evidence does not show

  • Paper counts measure research attention, not whether Melanotan II works or is safe.
  • No FDA review of any "research use only" product's identity, purity, sterility or dose.

Research suppliers that list Melanotan II

36 vendors in our directory listed a product matching Melanotan II in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.

Prices per mg, where we could verify them, are on our price comparison.

Melanotan II reconstitution math

Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.

Melanotan II FAQ

Is Melanotan II FDA-approved?

Melanotan II is not approved by the FDA for any use; products sold under this name are labeled for research use only, not for human consumption.

Is Melanotan II safe?

Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.

How much research is there on Melanotan II?

PubMed indexes 196 papers on Melanotan II (4 tagged as clinical trials) as of October 19, 2026.

Who sells Melanotan II?

Ascension Peptides, Atomik Labz, Biocollex Research, BioGenix Peptides, Bulk Peptide Supply, Core Peptides and 30 more listed it on their public catalogs when we checked; a listing is not an endorsement.

Head-to-head comparisons

PT-141 vs Melanotan II

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