Source: FDA labelTirzepatide

Tirzepatide up to 15 mg: the Zepbound label schedule

Zepbound label: 2.5 mg weekly for 4 weeks, then 5 mg; increase by 2.5 mg after at least 4 weeks per step. Maintenance 5, 10 or 15 mg; maximum 15 mg. Sources linked.

Updated October 2026. Reviewed by The Peptide Directory Editorial Team

Quickstart highlights

Starts at 2.5 mg once weekly for 4 weeks (a start-up dose, per label).
2.5 mg increments, each after at least 4 weeks on the current dose.
Maintenance 5, 10 or 15 mg; 15 mg is the label maximum.

Dosing table

Once-weekly subcutaneous Zepbound schedule per the FDA label (revised 08/2026). Earliest timing shown; escalation can be slower.
Step	Dose	Duration
Weeks 1–4	2.5 mg	4 weeks
Weeks 5–8	5 mg	≥4 weeks
Next step	7.5 mg	≥4 weeks
Next step	10 mg	≥4 weeks
Next step	12.5 mg	≥4 weeks
Maximum	15 mg	Maintenance

Protocol overview & notes

The label lists 5, 10 or 15 mg as maintenance doses for weight reduction, and 10 or 15 mg for obstructive sleep apnea. The SURMOUNT-1 trial tested 5, 10 and 15 mg arms for 72 weeks.

Storage & handling

Follow the patient information for the specific pen (single-dose pen or KwikPen).

How this works & references

Every row of the table above is copied from the source listed below; we change nothing except layout. If the source is revised, we update this page and its date.

Sources

ZEPBOUND (tirzepatide) prescribing information, FDA (2026)

Frequently asked questions

What is the maximum dose of tirzepatide?

15 mg once weekly, per the Zepbound label.

How fast can tirzepatide be increased?

In 2.5 mg steps, no sooner than every 4 weeks, per the label.

Does this page tell me what dose to take?

No. It mirrors the published label for reference only.