Lab arithmeticSS-31 (elamipretide)FDA-approved
SS-31 10 mg: dosing evidence and reconstitution math
A 10 mg vial of SS-31 mixed with 2 mL of diluent is 5 mg/mL, so 10 units on a U-100 syringe (0.1 mL) contain 500 mcg.
Is there an established dose?
Doses of the FDA-approved product (FORZINITY) are set by its FDA label, linked below; research-grade vials are not that product.
- FORZINITY on Drugs@FDA (STEALTH BIOTHERAPS)
- SS-31 (elamipretide) profile: FDA status, research volume and registered trials.
10 mg vial concentration table
Concentration = vial content ÷ diluent volume. A U-100 insulin syringe holds 1 mL in 100 units, so 1 unit = 0.01 mL.
| Diluent | Concentration | Per 10 units (0.1 mL) | Per 1 unit |
|---|---|---|---|
| 1 mL | 10 mg/mL | 1 mg | 100 mcg |
| 2 mL | 5 mg/mL | 500 mcg | 50 mcg |
| 3 mL | 3.333 mg/mL | 333 mcg | 33.3 mcg |
| 5 mL | 2 mg/mL | 200 mcg | 20 mcg |
Arithmetic only; it assumes the vial contains exactly what the label states. Independent tests often find vials under- or over-filled, which is why a lot's certificate of analysis matters.
Syringe units for a given amount
Units on a U-100 syringe needed to draw each amount from this 10 mg vial, by diluent volume. The amounts are fractions of the vial (1/50, 1/20, 1/10, 1/5), not dose suggestions.
| Amount | 1 mL diluent | 2 mL diluent | 3 mL diluent |
|---|---|---|---|
| 200 mcg | 2 units | 4 units | 6 units |
| 500 mcg | 5 units | 10 units | 15 units |
| 1 mg | 10 units | 20 units | 30 units |
| 2 mg | 20 units | 40 units | 60 units |
Units = amount ÷ concentration × 100. Draws above 100 units exceed a 1 mL syringe.
What the research covers
A PubMed search for "elamipretide"[tiab] returned 206 records (155 from the last five years), 15 indexed as clinical trials when checked on October 2026.
- Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.
- Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.
- Elamipretide: First Approval.
- Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
ClinicalTrials.gov lists 21 registered studies (search), including:
- A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)
- A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome
- Study of Healthy Aging and Physical Function With Elamipretide
- Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy
Where research vials are listed
24 suppliers in our directory list SS-31 (A–Z): Amino Amigos, Ascension Peptides, Atomik Labz, Backroad Aminos, Biocollex Research, BioGenix Peptides, Dynamic Peptide, JetPeps, and 16 more. A listing is not a quality endorsement; ask for a lot-specific certificate of analysis.
Storage & handling
Follow the storage statement on the product sheet or certificate of analysis. Lyophilized (freeze-dried) peptides are generally kept cold, dry and away from light; once reconstituted, stability is shorter and depends on the compound and diluent. Bacteriostatic water contains 0.9% benzyl alcohol as a preservative; sterile water does not.
Frequently asked questions
How much bacteriostatic water for a 10 mg SS-31 vial?
The diluent volume only sets the concentration: 1 mL gives 10 mg/mL, 2 mL gives 5 mg/mL and 3 mL gives 3.333 mg/mL. Smaller volumes are more concentrated, so each syringe unit holds more.
How much SS-31 is in 10 units?
At 2 mL of diluent, 10 units (0.1 mL) of a 10 mg vial contain 500 mcg; at 1 mL they contain 1 mg.
What is the dose of SS-31?
Doses of the FDA-approved product (FORZINITY) are set by its FDA label, linked below; research-grade vials are not that product.
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