InvestigationalMonoamine reuptake inhibitorWeight loss research
Tesofensine
Tesofensine is an investigational triple monoamine reuptake inhibitor (not a peptide) studied for obesity.
What is Tesofensine?
Tesofensine is an investigational triple monoamine reuptake inhibitor (not a peptide) studied for obesity. Tesofensine is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Key takeaways
- Tesofensine is an investigational compound: it has been studied in clinical trials but has no FDA approval.
- PubMed indexes 52 papers on Tesofensine (11 tagged as clinical trials) as of October 19, 2026.
- ClinicalTrials.gov lists 13 registered studies using Tesofensine.
- 2 vendors in our directory listed Tesofensine in their public catalog on October 19, 2026.
Structure
Regulatory & access status
Tesofensine is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on Tesofensine?
PubMed indexes 52 papers mentioning Tesofensine in the title or abstract, 5 of them from the last five years and 11 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- Tesofensine, a monoamine reuptake inhibitor for the treatment of obesity. — Curr Opin Investig Drugs, 2009 · review
- Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. — PLoS One, 2024
- Weight loss produced by tesofensine in patients with Parkinson's or Alzheimer's disease. — Obesity (Silver Spring), 2008
- Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. — Neuropsychopharmacology, 2010
- Expression of concern--effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. — Lancet, 2013
- Structural basis for pharmacotherapeutic action of triple reuptake inhibitors. — Nat Commun, 2025
Registered clinical studies
ClinicalTrials.gov lists 13 studies with Tesofensine as an intervention (see all). Most recent:
- Evaluation of Long Term Safety of Tesofensine in Patients With Obesity — NCT00481104 · Phase 2 · completed · started 2007-05
- Study of Tesomet With Open-label Extension in Subjects With Prader-Willi Syndrome — NCT05198362 · Phase 2 · withdrawn · started 2021-12-28
- Study to Investigate the Pharmacokinetic Profile — NCT03286829 · Phase 1 · completed · started 2017-12-18
- Effect of Tesofensine on Weight Reduction in Patients With Obesity. — NCT00394667 · Phase 2 · completed · started 2006-09
- Study of Tesomet With Open-label Extension in Subjects With Hypothalamic Obesity (HO) — NCT05147415 · Phase 2 · withdrawn · started 2021-11-11
What the evidence does not show
- Paper counts measure research attention, not whether Tesofensine works or is safe.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list Tesofensine
2 vendors in our directory listed a product matching Tesofensine in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
Prices per mg, where we could verify them, are on our price comparison.
Tesofensine reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
Tesofensine FAQ
Is Tesofensine FDA-approved?
Tesofensine is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Is Tesofensine safe?
Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.
How much research is there on Tesofensine?
PubMed indexes 52 papers on Tesofensine (11 tagged as clinical trials) as of October 19, 2026.
Who sells Tesofensine?
Modern Aminos, OmegAmino listed it on their public catalogs when we checked; a listing is not an endorsement.
Related compounds
SemaglutideLiraglutideTirzepatideAICARL-carnitineMOTS-cRetatrutideCagrilintideAll weight loss & glp-1