Sermorelin

Structure

What makes Sermorelin different?

Unlike ipamorelin, sermorelin acts on the GHRH receptor — the body's main "go" signal for growth hormone — rather than the ghrelin receptor.

How does Sermorelin work?

Stimulates pituitary GHRH receptors, increasing the natural pulsatile release of growth hormone, which in turn raises IGF-1.

What the clinical evidence actually shows

• BioDrugs (1999) review of sermorelin in pediatric GH deficiency.
• Evidence for adult "anti-aging" use is limited.

How much research exists on Sermorelin?

PubMed indexes 25 papers mentioning Sermorelin in the title or abstract, 15 of them from the last five years and 0 tagged as clinical trials (search run October 19, 2026; repeat the search).

Most relevant recent papers

• Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. — J Am Acad Orthop Surg Glob Res Rev, 2026 · review
• Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance. — Sports Med, 2026 · review
• Advances in the detection of growth hormone releasing hormone synthetic analogs. — Drug Test Anal, 2021
• A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review. — J Sports Med Phys Fitness, 2026 · review
• Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? — Clin Interv Aging, 2006
• Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. — BioDrugs, 1999

Registered clinical studies

ClinicalTrials.gov lists 27 studies with Sermorelin as an intervention (see all). Most recent:

• Estradiol-Receptor Blockade in Older Men and Women — NCT02271282 · Phase 1 · completed · started 2014-12
• VRS-317 in Adult Subjects With Growth Hormone Deficiency — NCT01359488 · Phase 1 · completed · started 2011-03
• Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency — NCT01060488 · Phase 3 · completed · started 2004-01
• Three Month Treatment of Growth Hormone Releasing Hormone (GHRH) in the Elderly — NCT01410799 · Phase 2 · terminated · started 2011-05
• Study of the Effect of Growth Hormone-Releasing Hormone Antagonist on Growth Hormone Release in Acromegaly — NCT00004332 · completed · started 1993-05

Side effects

Historically reported effects include injection-site reactions, flushing and headache.

Regulatory & access status

• Brand Geref was approved and later discontinued; compounded sermorelin is not an FDA-approved product.

Sourcing & safety

Prescribed by some clinics as a compounded product; also sold online as a research chemical (not for human use).

Doses in labels and trials

Reference only — copied from published research. Not a recommendation.

What the evidence does not show

• Adult anti-aging benefit in controlled trials.

Sermorelin FAQ

Related peptides & comparisons

IpamorelinTesamorelin Growth Hormone

References

1. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency, BioDrugs (1999), PMID 18031173
2. Sermorelin — PubChem compound summary (CID 16132413), PubChem

Sermorelin calculators

Lab arithmetic only: convert a mass to a volume or syringe units at a known concentration with the units converter, or work out a concentration with the reconstitution calculator.

Where to get Sermorelin legally

There is no FDA-approved Sermorelin product. Compounded versions depend on FDA's compounding rules, and "research use only" products are not for human use.

Get Sermorelin via telehealth

• Defy MedicalTelemedicine hormone clinic offering TRT, BHRT, GLP-1 weight-loss care and physician-supervised peptide therapy alongside lab work.
• Hone HealthMembership telehealth platform built around biomarker testing, with physician consults for testosterone, weight-loss and longevity treatments.
• Rex MDMen's telehealth service covering ED, testosterone and weight management, prescribing brand-name semaglutide and compounded sermorelin.
• Strut HealthTelehealth service with free physician visits that prescribes compounded treatments, including semaglutide, oral tirzepatide, sermorelin and NAD+.

Research suppliers that list Sermorelin

38 vendors in our directory listed a product matching Sermorelin in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.

• Amino AmigosCatalog item: “Sermorelin 10mg”
• Ascension PeptidesCatalog item: “Sermorelin (10MG)”
• Atomik LabzCatalog item: “BULK PACK Sermorelin – 10mg (10 VIALS)”
• Backroad AminosCatalog item: “Sermorelin 10mg”
• BioGenix PeptidesCatalog item: “Sermorelin 5mg”
• Biotech PeptidesCatalog item: “Sermorelin (5mg)”
• Bulk Peptide SupplyCatalog item: “Sermorelin 5 mg”
• Core PeptidesCatalog item: “Sermorelin – 5MG”
• CostidesCatalog item: “Sermorelin Acetate”
• Dynamic PeptideCatalog item: “Sermorelin Peptide 5mg”
• Eros PeptidesCatalog item: “Sermorelin 10MG”
• Evolve BioPepCatalog item: “Sermorelin 5mg”
• Extreme PeptidesCatalog item: “Sermorelin”
• Liberty PeptidesCatalog item: “Sermorelin (5mg)”
• Licensed PeptidesCatalog item: “Sermorelin 5mg (10 vials)”
• Modern AminosCatalog item: “Sermorelin”
• NuScience PeptidesCatalog item: “Sermorelin – 5mg”
• Paramount PeptidesCatalog item: “Sermorelin (10mg)”
• Peptide CraftersCatalog item: “Sermorelin (10mg)”
• Peptide PartnersCatalog item: “Sermorelin (10mg vials)”
• Peptide WorldwideCatalog item: “8MG Sermorelin (4 x 2mg vials) – $76.00”
• Peptide.ExpressCatalog item: “Sermorelin”
• Pharma Grade PeptidesCatalog item: “Sermorelin Peptide Buy”
• Pinnacle Peptide LabsCatalog item: “Sermorelin [5mg]”
• Polaris PeptidesCatalog item: “Sermorelin 10mg”
• Prime Lab PeptidesCatalog item: “Sermorelin — 10mg”
• Prime PeptidesCatalog item: “Sermorelin”
• ProtideHealthCatalog item: “Sermorelin”
• Pure Lab PeptidesCatalog item: “Sermorelin 10mg”
• Royal PeptidesCatalog item: “Sermorelin 10mgx10vials”
• San Diego PeptidesCatalog item: “Sermorelin”
• Science.bioCatalog item: “Sermorelin – Aliquot, 5mg”
• Southern AminosCatalog item: “Sermorelin 10MG”
• Sports Technology LabsCatalog item: “Sermorelin Peptide (5 mg)”
• Sunrise BioResearchCatalog item: “Sermorelin Acetate 10mg x 10vials, 100mg”
• Swiss ChemsCatalog item: “Sermorelin, 2mg”
• Voltera SciencesCatalog item: “Sermorelin Acetate”
• Xcel PeptidesCatalog item: “Sermorelin”

Prices per mg, where we could verify them, are on our price comparison.

Sermorelin dosing protocol

There is no FDA-label or published-trial dosing schedule we can reproduce for Sermorelin, so we don't publish one.

Find clinics offering Sermorelin

• Arctic Medical Center & SpaAnchorage, AK — named on the clinic's own website
• Belle MedicalAnchorage, AK — named on the clinic's own website
• Gameday Men's Health Anchorage, AKAnchorage, AK — named on the clinic's own website
• Precision Health AlaskaPalmer, AK — named on the clinic's own website
• Alison Wellness ClinicAthens, AL — named on the clinic's own website
• Gameday Men's Health Trussville, ALBirmingham, AL — named on the clinic's own website
• Alison Wellness ClinicHuntsville, AL — named on the clinic's own website
• BV Medical SolutionsHuntsville, AL — named on the clinic's own website
• Prime IV Hydration & Wellness - Huntsville-Jones ValleyHuntsville, AL — named on the clinic's own website
• Gameday Men's HealthMadison, AL — named on the clinic's own website
• Madison Wellness & Aesthetic CenterMadison, AL — named on the clinic's own website
• Gameday Men's Health Pelham, ALPelham, AL — named on the clinic's own website

759 verified clinics name Sermorelin; browse them by state.

Browse all clinics