InvestigationalAMPK activator (small molecule)Metabolic research
O-304
O304 is a small-molecule AMPK activator tested in early clinical studies in type 2 diabetes; it is not a peptide.
What is O-304?
O304 is a small-molecule AMPK activator tested in early clinical studies in type 2 diabetes; it is not a peptide. O-304 is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Key takeaways
- O-304 is an investigational compound: it has been studied in clinical trials but has no FDA approval.
- O-304 has little indexed research under its own name; we list only papers whose titles name it.
- 2 vendors in our directory listed O-304 in their public catalog on October 19, 2026.
Regulatory & access status
O-304 is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on O-304?
O-304 has no reliable PubMed search term of its own (the name is shared with unrelated terms), so we list only papers whose titles name it. Search PubMed.
Most relevant recent papers
- AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice. — Commun Biol, 2021
- AMPK Activator O304 Protects Against Kidney Aging Through Promoting Energy Metabolism and Autophagy. — Front Pharmacol, 2022
- Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice. — Sci Rep, 2021
- O304 is a mitochondrial uncoupler which extends C. elegans lifespan and induces vasorelaxation of rat mesenteric arteries. — Chem Biol Interact, 2025
- PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients. — JCI Insight, 2018
- O304 alleviates abdominal aortic aneurysm formation via AMPK/mTOR/MMP pathway activation. — Front Pharmacol, 2024
What the evidence does not show
- Paper counts measure research attention, not whether O-304 works or is safe.
- No clinical trial in humans is tagged in PubMed under this name.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list O-304
2 vendors in our directory listed a product matching O-304 in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
Prices per mg, where we could verify them, are on our price comparison.
O-304 reconstitution math
Lab arithmetic only, not dosing guidance: use the peptide calculator to turn a vial size and diluent volume into a concentration.
O-304 FAQ
Is O-304 FDA-approved?
O-304 is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Is O-304 safe?
There are no published human safety trials of O-304 that we could find. Products sold as "research use only" have no FDA review of purity, sterility or dose, and are not for human use.
How much research is there on O-304?
O-304 has little indexed research under its own name; we list only papers whose titles name it.
Who sells O-304?
Modern Aminos, Xcel Peptides listed it on their public catalogs when we checked; a listing is not an endorsement.
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