InvestigationalGLP-1 / glucagon dual agonistWeight lossdiabetes
Mazdutide
Mazdutide (IBI362/LY3305677) is a GLP-1 and glucagon receptor dual agonist developed by Innovent and Lilly, approved in China and studied in obesity and type 2 diabetes.
What is Mazdutide?
Mazdutide (IBI362/LY3305677) is a GLP-1 and glucagon receptor dual agonist developed by Innovent and Lilly, approved in China and studied in obesity and type 2 diabetes. Mazdutide is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Key takeaways
- Mazdutide is an investigational compound: it has been studied in clinical trials but has no FDA approval.
- PubMed indexes 54 papers on Mazdutide (9 tagged as clinical trials) as of October 19, 2026.
- ClinicalTrials.gov lists 43 registered studies using Mazdutide.
- 8 vendors in our directory listed Mazdutide in their public catalog on October 19, 2026.
Regulatory & access status
Mazdutide is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Sellers that market unapproved peptides for human use can receive FDA warning letters; our vendor directory links any letter we found on fda.gov.
How much research exists on Mazdutide?
PubMed indexes 54 papers mentioning Mazdutide in the title or abstract, 54 of them from the last five years and 9 tagged as clinical trials (search run October 19, 2026; repeat the search).
Most relevant recent papers
- Once-Weekly Mazdutide in Chinese Adults with Obesity or Overweight. — N Engl J Med, 2025 · clinical trial
- Mazdutide: First Approval. — Drugs, 2025 · review
- Mazdutide versus placebo in Chinese adults with type 2 diabetes. — Nature, 2026 · clinical trial
- Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes. — Nature, 2026 · clinical trial
- Efficacy and Safety of Mazdutide in Chinese Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial. — Diabetes Care, 2024 · clinical trial
- Emerging pharmacotherapies for obesity: A systematic review. — Pharmacol Rev, 2025 · review
Registered clinical studies
ClinicalTrials.gov lists 43 studies with Mazdutide as an intervention (see all). Most recent:
- A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity — NCT06862908 · Phase 2 · active not recruiting · started 2025-03-26
- A Study of Multiple Doses of LY3305677 in Healthy Participants — NCT03325387 · Phase 1 · completed · started 2017-10-27
- A Study of IBI362 in Poorly Controlled Type 2 Diabetes Patients Only Through Diet and Exercise — NCT05628311 · Phase 3 · completed · started 2023-01-06
- A Study of LY3305677 in Participants With Obesity Or Overweight — NCT05623839 · Phase 1 · completed · started 2022-11-16
- Pharmacokinetics of IBI362 in Subjects With and Without Renal Impairment — NCT05793450 · Phase 1 · completed · started 2023-05-05
What the evidence does not show
- Paper counts measure research attention, not whether Mazdutide works or is safe.
- No FDA review of any "research use only" product's identity, purity, sterility or dose.
Research suppliers that list Mazdutide
8 vendors in our directory listed a product matching Mazdutide in their public catalog on October 19, 2026. Listed alphabetically; a listing is not an endorsement. Research use only.
- Bulk Peptide Supply
- Eros Peptides
- Extreme Peptides
- Modern Aminos
- Polaris Peptides
- Pure Lab Peptides
- Southern Aminos
- Xcel Peptides
Prices per mg, where we could verify them, are on our price comparison.
Mazdutide reconstitution math
Lab arithmetic only, not dosing guidance: vial-by-vial concentration tables are on Mazdutide 10 mg vial math.
Mazdutide FAQ
Is Mazdutide FDA-approved?
Mazdutide is an investigational compound: it has been studied in clinical trials but has no FDA approval.
Is Mazdutide safe?
Safety data come from the published studies listed on this page; read them in full. Products sold as "research use only" have no FDA review of their purity, sterility or dose.
How much research is there on Mazdutide?
PubMed indexes 54 papers on Mazdutide (9 tagged as clinical trials) as of October 19, 2026.
Who sells Mazdutide?
Bulk Peptide Supply, Eros Peptides, Extreme Peptides, Modern Aminos, Polaris Peptides, Pure Lab Peptides and 2 more listed it on their public catalogs when we checked; a listing is not an endorsement.
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